[ China Pharmaceutical Network Science and Technology News ] It is reported that the research team of the Shanghai Institute of Materia Medica, Yang Yushe, of the Chinese Academy of Sciences, used the clinical phase I BAL30072 as the lead compound to design and synthesize a series of iron carrier-monocyclic β-lactam conjugate compounds through structural optimization strategies. The candidate compound 12c was discovered through in-depth study of structure-activity relationship and conformational relationship.
Bacterial resistance, especially the resistance of Gram-negative bacteria, has become a major threat to human health. At present, there is a serious lack of safe and effective drugs for the treatment of multi-drug resistant Gram-negative bacteria, which is globally There are very few drug candidates for clinical research. In 2017, WHO divided the three categories into extremely important, important and medium-important categories based on the urgent need for new antibiotics. Listed as extremely important, including carbapenem-resistant Acinetobacter baumannii (CRA), Pseudomonas aeruginosa and extended-spectrum β-lactamase (ESBLS) Enterobacteriaceae (CRE) three bacteria, It is a multidrug resistant Gram-negative bacterium. Therefore, the development of broad-spectrum, potent anti-multidrug-resistant Gram-negative bacteria is a very urgent clinical demand.
The development of highly effective anti-multidrug-resistant Gram-negative bacteria is a world problem, because the resistance mechanism of negative bacteria is far more complicated than that of positive bacteria. The decrease of the outer membrane permeability of Gram-negative bacteria is an important reason for its multidrug resistance and pan-drug resistance. The principle of using iron from the bacterial iron carrier to skillfully combine antibiotics with iron carriers is to overcome the problem. An effective strategy for the barrier of outer membrane permeability of gram-negative bacteria. The research team of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Yang Yushe, used the clinical phase I BAL30072 as the lead compound. Through the structural optimization strategy, a series of iron carrier-monocyclic β-lactam conjugated compounds were designed and synthesized through in-depth structure-activity relationship and formation. In relational studies, candidate compound 12c was found (Fig., YT-14). YT-14 in vitro multidrug-resistant Acinetobacter baumannii (OXA23), Klebsiella pneumoniae (KPC-2), Pseudomonas aeruginosa (IMP4), extended-spectrum β-lactamase (ESBLS) large intestine Both bacilli have strong inhibitory activity. In a mouse model of multidrug-resistant K. pneumoniae (KPC-2) infection, YT-14 has a stronger protective effect in mice than BAL30072 and meropenem. In conclusion, YT-14 has potent, broad-spectrum anti-multidrug-resistant Gram-negative bacteria activity and excellent metabolic properties. It is a promising candidate compound against Gram-negative bacteria and deserves further research and development.
The research was published online March 13 in the Journal of Medicinal Chemistry, the journal of the American Chemical Society. The research work was mainly carried out by Yang Liangshe, a researcher at the Shanghai Institute of Materia Medica, and Wang Haidong, a professor at Jiaxing College. They were completed by Tan Liang and Tao Junliang (co-cultivation).
The study was funded by the National Natural Science Foundation of China and the Shanghai Institute of Drugs.
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Outdoor Camera
When installing security Outdoor Camera, you should first choose the monitoring host. Do you want to add a monitoring card to your computer, or do you want to use an embedded hard disk recorder as your monitoring host. The computer monitoring card is more suitable for places that are familiar with computer installation, have professional personnel on duty, and have more functional requirements. Its overall investment is relatively low. Since the monitoring card is installed in the computer, the computer needs to be started 24 hours a day; As for the latter, it does not require professional knowledge, nor does it need to be on duty, and it is relatively simple to operate.
To install security monitoring equipment, it is necessary to determine how many cameras are installed, and the quality and monitoring range of the cameras are affected. It is preferred to determine how many cameras are used for monitoring, and then determine the camera lens monitoring range according to how many cameras are available. Therefore, the distance from the camera to the monitoring point and the monitoring area must be clear. The infrared supply network recommends using the camera of 480 TV line, because it is more in line with that definition.
When installing security monitoring equipment, the third consideration is whether the camera has night vision function. If the monitoring is installed in a dark place, it is necessary to consider using a camera with infrared night vision function.
The security monitoring equipment can be installed via wired or wireless transmission. Although the cost of wireless network is relatively high, it can save a lot of installation trouble and make the monitoring site more beautiful. However, the installation of wireless network monitoring equipment should take into account the environmental problems of security sites. Cement building materials will shorten the wireless transmission distance, and metal building materials may complete the shielding of wireless signals. The infrared transmitter and infrared receiver should be far away from other appliances to avoid interference. Because the price of wireless network is almost twice that of wired transmission monitoring equipment, I suggest using wired transmission installation.
On site monitoring and network monitoring When determining the installation of the monitoring system, you should consider whether you need network functions. That is, if you need to monitor and control the monitoring site on the Internet at any time, you need to select a monitoring host with network functions. Avoid no network transmission function after installation.
A complete security monitoring equipment should at least have three parts: surveillance camera, PTZ and decoder. The following are their installation methods:
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