- Model NO.: 849217-68-1
- Customized: Non-Customized
- Suitable for: Elderly, Adult
- Purity: >99%
- Mf: C28h24fn3o5
- Trademark: YC
- Specification: ISO9001: 2008
- HS Code: 3001909099
- Powder: Yes
- Certification: GMP, HSE, ISO 9001, USP, BP
- State: Solid
- CAS: 849217-68-1
- MW: 502
- Transport Package: Foil Bag/Tin or as Your Request
- Origin: China
CAS No.849217-68-1
Chemical Name:Cabozantinib
SynonymsXL184;XL-186;BMS907351;Cabozantinib;Carbozantinib;Cabozantinib Base;XL184 Cabozantinib;Cabozantinib, >=98%;Cabozantinib(XL184);Cabozantinib(BMS907351)
CBNumber:CB72525898
Molecular Formula:C28H24FN3O5
Formula Weight:502
Anti-cancer drugs
Cabozantinib is a kind of a novel type of molecular targeted drugs developed by the United States Exelixis biopharmaceutical company. On November 29, 2012, the US Food and Drug Administration (FDA) approved the use of cabozantinib for the treatment of unresectable malignant local advanced or metastatic medullary thyroid carcinoma.
In addition, Sorafenib, Vandernib and Levotinib have been approved by the Food and Drug Administration (FDA) for the treatment of advanced thyroid cancer.
Side effects
In clinical trials, common adverse effects caused by cabozantinib include diarrhea, stomatitis, palmar-plantarrythrodysesthesia syndrome (PPES), and loss of weight, loss of appetite, nausea, fatigue, oral pain, taste disorders, high blood pressure, abdominal pain and constipation.
The most common laboratory abnormalities (> 25%) were increased aspartate aminotransferase, alanine aminotransferase, lymphopenia, increased alkaline phosphatase level, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia and hyperbilirubinemia.
For patients receiving cabozantinib, 57% of patients have gotten increased level of thyroid stimulating hormone after initial dose, compared with patients receiving placebo, increased by 19%.
Uses
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively
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