High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus

Model NO.: 104987-11-3
Name: Tacrolimus
CAS: 104987-11-3
Sample: Free
Shipping: Safe
Market: Global
Delivery: Door to Door Service
Trademark: saichuang
Transport Package: as You Requiry
Specification: 99%
Origin: China
HS Code: 3001200090
Model NO.: 104987-11-3
Name: Tacrolimus
CAS: 104987-11-3
Sample: Free
Shipping: Safe
Market: Global
Delivery: Door to Door Service
Trademark: saichuang
Transport Package: as You Requiry
Specification: 99%
Origin: China
HS Code: 3001200090
Product name: Tacrolimus
Other Name: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide;
Original: China
CAS: 104987-11-3
Molecular formula: C44H69NO12
MW: 804.02
Brand name Shuou
Leading time within 24 hours upon receipt of payment
Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity 99%
Package Discreet and Hidden package according to specific requirement
Appearance White crystal powder
Certification SGS, ISO 9001, KOSHER
Payment Terms Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity 10g
Price Negotiable
 
Description of Active Pharmaceutical Ingredients Tacrolimus :
 
1. Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response.
 
2. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
3. Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
Medical Usage of Active Pharmaceutical Ingredients Tacrolimus:
 
Immunosuppression following transplantation:
 
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and IL-2 receptor inhibitors such as basiliximab. Dosages are titrated to target blood levels.
 
Ulcerative colitis:
 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Dermatological use:
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way tosteroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.

It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 
Technical Testing Sheet of Active Pharmaceutical Ingredients Tacrolimus:
 
COA:
 

 
Test Items Specification Results
Identification (IR) Should match with working standard Confirms
Solubility   Confirms
Melting point 246.0~252.0ºC 246.0ºC~248.0ºC
Water by KF Not more than 0.5% 0.14%
Loss on drying Not more than 0.5% 0.17%
Residue on ignition Not more than 0.2% 0.05%
Heavy Metals Not more than 20ppm Confirms
Single maximum impurity Not more than 0.5% 0.34%
Total impurities Not more than 1.0% 0.66%
Assay by HPLC 98.0% -102.0% 101.0%
Conclusion conforms with USP 32 Standard
 
How to Complete an Order

 
Make an order 1.Please let me know the items you are looking for, quantity, and the destination country;
2.You confirm all details, and offer us purchasing order;
3.We send the detail price of our product and offer the suitable shipping method for reference;
4.You confirm the order and pay money 100% in advance and send us the detail address.
5.We arrange the shipment according to your requirements.
6.We offer after-sales service after you receive parcel.
Shipping Provide your addressee info. ( phone number , zip code )
Packing According to different countries and quantity of orders
Lead Time Arranged within 12 hours upon receipt of your payment
Photos Photos of parcel would be offered to tell apart the steroids in advance
Delivery Time Usually 4-6 working days to reach destinations
Tracking number Offered once it is released on the Net .Normally within 24hours upon the receipt of payment.
After-sale service 24/7 online for problems and concern related to steroids

High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus
High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus
 
Product name: Tacrolimus
Other Name: (2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dim;6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-5;fr900506;prograf;tsukubaenolide;
Original: China
CAS: 104987-11-3
Molecular formula: C44H69NO12
MW: 804.02
Brand name Shuou
Leading time within 24 hours upon receipt of payment
Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity 99%
Package Discreet and Hidden package according to specific requirement
Appearance White crystal powder
Certification SGS, ISO 9001, KOSHER
Payment Terms Western Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity 10g
Price Negotiable
 
Description of Active Pharmaceutical Ingredients Tacrolimus :
 
1. Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response.
 
2. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
3. Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
 
Medical Usage of Active Pharmaceutical Ingredients Tacrolimus:
 
Immunosuppression following transplantation:
 
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and IL-2 receptor inhibitors such as basiliximab. Dosages are titrated to target blood levels.
 
Ulcerative colitis:
 
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
 
Dermatological use:
 
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way tosteroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.

It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
 
Technical Testing Sheet of Active Pharmaceutical Ingredients Tacrolimus:
 
COA:
 

 
Test Items Specification Results
Identification (IR) Should match with working standard Confirms
Solubility   Confirms
Melting point 246.0~252.0ºC 246.0ºC~248.0ºC
Water by KF Not more than 0.5% 0.14%
Loss on drying Not more than 0.5% 0.17%
Residue on ignition Not more than 0.2% 0.05%
Heavy Metals Not more than 20ppm Confirms
Single maximum impurity Not more than 0.5% 0.34%
Total impurities Not more than 1.0% 0.66%
Assay by HPLC 98.0% -102.0% 101.0%
Conclusion conforms with USP 32 Standard
 
How to Complete an Order

 
Make an order 1.Please let me know the items you are looking for, quantity, and the destination country;
2.You confirm all details, and offer us purchasing order;
3.We send the detail price of our product and offer the suitable shipping method for reference;
4.You confirm the order and pay money 100% in advance and send us the detail address.
5.We arrange the shipment according to your requirements.
6.We offer after-sales service after you receive parcel.
Shipping Provide your addressee info. ( phone number , zip code )
Packing According to different countries and quantity of orders
Lead Time Arranged within 12 hours upon receipt of your payment
Photos Photos of parcel would be offered to tell apart the steroids in advance
Delivery Time Usually 4-6 working days to reach destinations
Tracking number Offered once it is released on the Net .Normally within 24hours upon the receipt of payment.
After-sale service 24/7 online for problems and concern related to steroids

High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus
High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus
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