Release date: 2009-09-22
Researchers reported in a recent online journal Nature-Medical that a special primate variant potassium channel affects cerebral cortical function, cognition, and neuronal physiology, and may increase schizophrenia. risks of. The identification of this new variant potassium channel provides a new approach to the treatment of schizophrenia. Organized neuronal discharge is an important factor in the functioning of the brain, but in patients with schizophrenia, this mechanism of discharge is disrupted. Daniel Weinberger and colleagues identified a special, brain-derived potassium channel, KCNH2, in the long-lived animals that manipulated the discharge of neurons. The hippocampus is the core area of ​​cognition associated with the brain. Controlled comparative studies have shown that KCNH2 is expressed in the brain of schizophrenia patients compared to normal subjects in the control group. In collaboration with colleagues, Weinberger analyzed 367 families, 1158 unrelated cases, and 1704 control subjects who found a single nucleotide polymorphism associated with schizophrenia in KCNH2. Risk-related polymorphisms mean low levels of intelligence, slow cognitive processes, altered memory, and high levels of hippocampal mRNA in KCNH2 variants. They found that overexpression of the KCNH2 variant channel in neurons accelerated the stagnation of potassium flux, leading to frequent, persistent neuronal firing, which helps explain the mechanism of neurological disorders in patients. Meditech Medical Network
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