LONDON, November 2 — Researchers have revealed in a study published in the prestigious journal *Nature Genetics* that two specific genetic variations may raise the risk of lung cancer by as much as 60%. The findings, published on the 2nd, mark a significant step forward in understanding the genetic factors behind this deadly disease.
The international research team, comprising scientists from 18 countries, analyzed genetic data from a large sample group. The study involved 6,000 individuals diagnosed with lung cancer and 9,000 without the disease. By comparing their DNA, the researchers identified mutations in two genes—TERT and CRR9—located on a specific region of chromosome 5. These mutations were found to be strongly associated with an increased susceptibility to lung cancer.
While smoking remains the primary known cause of lung cancer, the study highlights that not all smokers develop the disease, and some non-smokers do. This inconsistency has driven scientists to explore other contributing factors, including genetic predispositions. The discovery could pave the way for more personalized screening and prevention strategies in the future.
According to the American Cancer Society, lung cancer remains the leading cause of cancer-related deaths among men globally and the second leading cause among women. With these new insights, researchers hope to improve early detection and treatment options for those at higher genetic risk.
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