New drugs can replace opioids to relieve pain
March 17, 2017 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The study was led by Val Watts, a professor of medicinal chemistry and molecular pharmacology at Purdue University School of Pharmacy. He believes that this compound is capable of inhibiting the activity of adenylate cyclase 1 with high selectivity.
Adenylate cyclase is capable of catalyzing the production of adenine mononucleotides, which are important bio-messages for many organisms. Different subtypes of 10 adenylate cyclases have been discovered in humans, and a large number of studies have shown that adenylate cyclase 1 is a potential target for the treatment of chronic pain. The newly discovered compound has a significantly higher inhibitory effect on adenylate cyclase 1 than the other nine subtypes.
“Based on this finding, we are able to effectively treat chronic pain and avoid the side effects of opium.†One of the researchers, Richard van Rij, an associate professor from the School of Pharmacy, said: “There are many problems with the use of opium to treat chronic pain. Including improper dosage, etc. Although it has a good effect as a treatment for acute pain, it still needs careful selection in the treatment of chronic pain.
Opium is a generic term for a class of drugs, including heroin (prohibited items) and other prescription painkillers, including oxycodone, hydrocodone, codeine, morphine, fentanyl, and so on. They all bind to opioid receptors on the surface of nerve cells, creating a sense of pleasure and eliminating the feeling of pain.
According to the Centers for Disease Control and Prevention, from 1999 to 2015, the overdose of opium was over four times as a result of prescription drugs, during which time 183,000 people in the United States died from overuse of prescription opium.
The most recent study found a compound that specifically blocks adenylate cyclase 1. Of course, this study is still in its infancy, but the drug may have a role in reducing opium dependence.
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