Release date: 2017-03-28
Recently, a research report published in the international magazine Genes & Development, scientists from the Mayo Clinic identified a key enzyme that regulates the BRCA2 pathway, UCHL3. The BRCA2 pathway is very important for DNA repair of cells. important.
Researcher Dr. Zhenkun Lou pointed out that DNA can create a beautiful blueprint for our body, and DNA repair is also a basic mechanism in cells, which can help inhibit the accumulation of DNA mutations and the occurrence of human diseases; BRCA2 pathway is DNA repair A key pathway, the BRCA2 gene mutation is directly related to the increased risk of cancer in individuals, especially associated with increased risk of breast and ovarian cancer.
UCHL3 enzyme is highly expressed in some cancers, but it is in a mutant or deleted state in other types of cancer. Cancer cells with high levels of UCHL3 expression are resistant to chemotherapy, whereas cells with low expression of UCHL3 are cancer cells. It is sensitive to chemotherapy, so the expression of UCHL3 enzymes may help researchers develop more precise cancer therapies.
Lou said that the enzyme UCHL3 may be a potential therapeutic target to help scientists develop new therapies to overcome the chemotherapeutic tolerance of cancer cells with high expression of UCHL3. At the same time, we can also use the UCHL3 gene clinically. A biomarker to guide the development of individualized therapies.
Finally, the researchers pointed out that of course, in the later stage, we need to conduct more in-depth research to develop more new treatments to treat women's multiple cancers, thus improving women's health.
Source: Bio Valley
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