Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii.
Diagnostic points
(1) Popular features
It often occurs in summer and autumn, in hot and humid areas, especially in 3-5 months old piglets. The disease can be infected by the placenta of the sow, causing premature birth or dysplasia of the pregnant sows or stillbirth; in addition, digestive tract infections, respiratory mucosal infections and mechanical transmission of blood-sucking insects.
(2) clinical features
The clinical symptoms of this disease are similar to those of swine fever and swine flu. The initial temperature of the disease increased by about 40-42 ° C, and the stay was 7-10 days. The appetite was reduced or abolished, constipation. The skin of the ears, lips and lower extremities is blemishes or has blood spots. Breathing fast, the nose is dry and has a nose leak, coughing, difficulty breathing, foaming in the mouth, suffocation and death.
(3) necropsy lesions
Mainly high lung edema, lobular interstitial widening, lobular interstitial filled with translucent jelly-like exudate, a large amount of mucous foam in the trachea and bronchi, and some complicated with pneumonia. The lymph nodes of the whole body were swollen and there was a small necrosis. The liver is slightly swollen, grayish red, with small necrosis scattered; the spleen is slightly swollen red; the mesenteric lymph nodes are cystic.
Laboratory diagnosis
(1) Direct smear
The liver, spleen, lungs and lymph nodes were taken as smears, stained with Giemsa or Reiter's solution, and the crescent-shaped or fusiform worms were found under the oil microscope. The nucleus was red and the cytoplasm was blue. .
(2) Animal inoculation
A 1:10 emulsion was prepared from sick pig blood or liver, spleen and brain tissue. The mice were intraperitoneally injected with 0.2 ml. After 20 days of observation, a large number of worms were found in the ascites or liver, spleen and lymph nodes of the mice. At the beginning of the disease, the Toxoplasma gondii can be found in the blood, and the serological diagnosis can be performed by a staining test, an indirect agglutination test, or an enzyme-linked adsorption test.
Control method
(1) The use of sulfa drugs can control the development of this disease, reduce mortality and shorten the course of disease. The following valid prescriptions are available;
1) Aminazine (SD) + amidopyrimidine; the former is 70 mg / kg body weight, the latter is 6 mg / kg body weight, taken orally, twice a day, for the first time, for 3-5 days.
2) synergistic sulfa-5-methoxyuracil (containing 10% sulfa-5-methoxypyrimidine and 2% trimethoprim); intramuscular injection of 10 kg body weight not more than 2 ml, once a day, used 3 -5 days.
3) Sulfonamide-6-methoxypyrimidine (SMM); according to 60 mg / kg body weight, formulated into 10% injection solution intramuscular injection, once a day, for 3-5 days, or the first dose of 0.05-0.1 g / kg Body weight, maintenance amount 0.025-0.05 g / kg body weight, 2 times a day. For 3-5 days in a row; or take the first amount of 0.05-0.1 g / kg body weight, maintain the amount of 0.025-0.05 g / kg body weight, 2 times a day. For 3-5 days in a row; or (SMM) plus DVD (Netizen) synergist, mixed at 5:1, oral mixture 60 mg / kg body weight.
(2) Feeding pigs with more than 100 grams of Daqingye every day, and even feeding for 5-7 days, it has the effect of preventing the onset and shortening the course of disease.
(3) It is necessary to prevent rats from killing rats and prevent forage and feed from being contaminated by rats and cat feces. It is forbidden to feed pigs with uncooked slaughter waste and kitchen waste.
(4) Strengthen environmental sanitation and disinfection. Because the oocyst can resist acid and alkali and common disinfectant, it can be disinfected by using flame, 3% caustic soda, 1% to Suer, 0.5% ammonia, and sun exposure.
1.Hawthorn extract
Hawthorn can enhance myocardial contractility, increase cardiac output, slow down heart rate, dilate coronary blood vessels, and has the effect of lowering blood pressure and blood fat.
2.Rhubarb extract
In addition to laxative and laxative effect, rhubarb also has the effect of lowering blood pressure and cholesterol.
3, wolfberry extract
Lycium barbarum can lower blood sugar, inhibit fat deposition in liver cells, promote liver cell newborn, and have antihypertensive effect.
4, Cordyceps extract
Cordyceps can improve the immune function of the body, strengthen the ability to remove viruses, protect liver cells and indirectly inhibit the occurrence and development of liver fibrosis.
5. Salvia miltiorrhiza extract
Salvia miltiorrhiza is used in more research on anti-hepatic fibrosis treatment. It can protect hepatocytes, reduce the stimulation of stellate cells by hepatocyte injury, necrosis, etc., and inhibit the initiation and development of hepatic fibrosis; the collagen content in the liver is significantly reduced, and the urinary HPP discharge is elevated, suggesting that the drug can promote the degradation of collagen that has been formed, and the proliferating collagen is reabsorbed by hydrolysis.
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