Release date: 2017-11-03
Fat, arguably the enemy of most girls, there is no shortage of research on how to reduce body fat in major journals. But recently, a study from McMaster University showed that a diabetes drug that promotes the growth of fat cells in the bone marrow can indirectly kill cancer cells by enhancing the way of fat cells, allowing us to look at fat.
Adipocytes can "crowd away" cancer cells to make healthy blood cells vacate, thus achieving the treatment of myeloid leukemia (AML). Related research is published in the recent Nature issue of Nature Cell Biology, entitled "Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche".
AML urgently needs new treatments
The production of healthy red blood cells is critical for AML patients, but is sometimes overlooked because conventional treatments focus on killing leukemia cells alone. Patients with this disease suffer from anemia and infection due to failure to produce healthy blood, all of which are the leading cause of hospitalization and death.
Conventional treatment of acute myeloid leukemia (AML) is primarily directed at killing leukemia cells and has not resulted in significant changes in standard treatments in recent decades. And this study reveals a new treatment – ​​indirect treatment. It is welcome to change the bone marrow microenvironment to make it beneficial for the formation of healthy blood cells and is not conducive to the formation of leukemia cells.
New methods inhibit cancer cells and promote healthy cell production
The study revealed a previously unrecognized relationship between the formation of adipocytes in the bone marrow and normal bone marrow erythrocyte maturation. And this relationship provides a good treatment for myeloid leukemia, improving the symptoms of failure in patients with myeloid leukemia.
The study took three and a half years to begin with observations of leukemia patients. The next study was to collect bone marrow samples from a large number of patients at the Ottawa Hospital Institute, Western University and the Hamilton Health Science Center. Completed. The study also included a detailed study and imaging of healthy cells and cancer cells present in bone marrow (BM), revealing the role of fat cells.
Dr. Mick Bhatia, the author of the paper and director and senior scientist at the McMaster Stem Cell and Cancer Research Center, said: "The focus of chemotherapy and existing standard treatments is to kill cancer cells, and we have adopted different strategies to change cancer. The living environment of the cells is treated. This not only inhibits the "bad" cancer cells, but also enhances the "good" healthy cells, allowing them to regenerate in a new drug-induced environment."
Initiating new treatment ideas
The article also points out that the drugs used in the study to treat diabetes, which induces the production of fat cells in the bone marrow, have been found to help promote erythropoiesis and inhibit leukemia.
Dr. Allison Boyd, the first author of the study, said: "Our approach represents a different approach to observing leukemia and treats the entire bone marrow as an ecosystem rather than traditional research and Try to kill the diseased cells directly."
This will become a potential new treatment that can be added to current treatments and even replace other drugs in the near future. The fact that this drug activates blood regeneration provides us with new therapeutic ideas for waiting for bone marrow. In transplant patients, this therapy may activate healthy cells in the bone marrow to benefit them.
Reference material
1, Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche
2, Leukemia May Shrivel If Fat Cells in Marrow Are Plumped
Source: Translational Medicine Network (micro signal zhuanhuayixue)
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